It happened on Ezra Church Drive at about 2:30 a.m.
Atlanta police said when they arrived at the scene, they found the teen suffering from a gunshot wound to the stomach and another person grazed by a bullet.
The victims told police that someone chased them on Interstate 20 and opened fire following an altercation at a nightclub on Moreland Avenue.
Police said the shots also shattered the back glass of the victims' vehicle and deflated a tire.
Both victims were taken to Grady Hospital.
Police said the perpetrators were traveling in a newer model Nissan Altima.