Kierra Fletcher added 12 points for the 10th-seeded Yellow Jackets (18-12), who shot 46 percent and led by as many as 16. They also finished with 15 points off turnovers.
Georgia Tech advanced to Thursday's second round to face Virginia, the tournament's No. 7 seed.
Kobi Thornton had 13 points and 13 rebounds for 15th-seeded Clemson (11-19), which lost its 11th straight game. The Tigers shot just 29 percent and made 4 of 18 3-pointers.
Clemson got as close as four points midway through the fourth quarter but couldn't complete a comeback.
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